Structure of the gene encoding rat thyrotropin releasing hormone.

  title={Structure of the gene encoding rat thyrotropin releasing hormone.},
  author={S L Lee and Katrina Stewart and Richard Goodman},
  journal={The Journal of biological chemistry},
  volume={263 32},
The gene encoding the hypothalamic peptide thyrotropin releasing hormone (TRH) was isolated from two rat genomic bacteriophage libraries. Southern blot analysis indicates that the gene is present as a single copy in the rat genome. The transcriptional unit is 2.6 kilobases in size and contains three exons interrupted by two introns of approximately 750 and 450 base pairs. Exon 1 encodes the 5'-untranslated region of the mRNA, exon 2 encodes the signal sequence and the majority of the amino… CONTINUE READING