Structure of the gene encoding dihydrolipoyl transacylase (E2) component of human branched chain alpha-keto acid dehydrogenase complex and characterization of an E2 pseudogene.

@article{Lau1992StructureOT,
  title={Structure of the gene encoding dihydrolipoyl transacylase (E2) component of human branched chain alpha-keto acid dehydrogenase complex and characterization of an E2 pseudogene.},
  author={Kim S. Lau and William J Herring and Jacinta L. Chuang and Michael Mckean and Dean J. Danner and Rody P. Cox and David T Chuang},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 33},
  pages={24090-6}
}
We have determined the structural organization of the dihydrolipoyl transacylase (E2) gene of the human branched chain alpha-keto acid dehydrogenase complex. The single copy E2 gene spans approximately 68 kilobases of genomic DNA. The complete coding region consisting of the 5'- and 3'-untranslated regions, the mitochondrial targeting sequence (61 amino acids), and the mature E2 sequence (421 amino acids) are encoded by 11 exons ranging from 62 to 2239 base pairs. All the donor and acceptor… CONTINUE READING