Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin

@article{Schumacher2001StructureOT,
  title={Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin},
  author={Maria A. Schumacher and Andre F. Rivard and Hans Peter B{\"a}chinger and John P Adelman},
  journal={Nature},
  year={2001},
  volume={410},
  pages={1120-1124}
}
Small-conductance Ca2+-activated K+ channels (SK channels) are independent of voltage and gated solely by intracellular Ca2+. These membrane channels are heteromeric complexes that comprise pore-forming α-subunits and the Ca2+-binding protein calmodulin (CaM). CaM binds to the SK channel through the CaM-binding domain (CaMBD), which is located in an intracellular region of the α-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when Ca2+ binds the EF hands in the N… CONTINUE READING
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