Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus.

@article{Perbandt2008StructureOT,
  title={Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus.},
  author={Markus Perbandt and Jana H{\"o}ppner and C. D. Burmeister and Kai L{\"u}ersen and Christian Betzel and Eva Liebau},
  journal={Journal of molecular biology},
  year={2008},
  volume={377 2},
  pages={501-11}
}
Onchocerciasis or river blindness, caused by the filarial worm Onchocerca volvulus, is the world's second leading infectious cause of blindness. In order to chronically infect the host, O. volvulus has evolved molecular strategies that influence and direct immune responses away from the modes most damaging to it. The O. volvulus GST1 (OvGST1) is a unique glutathione S-transferase (GST) in that it is a glycoprotein and possesses a signal peptide that is cleaved off in the process of maturation… CONTINUE READING

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