Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification.

@article{Yakubovskaya2012StructureOT,
  title={Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification.},
  author={Elena Yakubovskaya and Kip E. Guja and Edison Mejia and Steven Castano and Elena Hambardjieva and Woo Suk Choi and Miguel Garcia-Diaz},
  journal={Structure},
  year={2012},
  volume={20 11},
  pages={1940-7}
}
MTERF4 is the first MTERF family member shown to bind RNA and plays an essential role as a regulator of ribosomal biogenesis in mammalian mitochondria. It forms a complex with the rRNA methyltransferase NSUN4 and recruits it to the large ribosomal subunit. In this article, we characterize the interaction between both proteins, demonstrate that MTERF4 strongly stimulates the specificity of NSUN4 during in vitro methylation experiments, and present the 2.0 Å resolution crystal structure of the… CONTINUE READING
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