Structure of the endonuclease domain of MutL: unlicensed to cut.


DNA mismatch repair corrects errors that have escaped polymerase proofreading, increasing replication fidelity 100- to 1000-fold in organisms ranging from bacteria to humans. The MutL protein plays a central role in mismatch repair by coordinating multiple protein-protein interactions that signal strand removal upon mismatch recognition by MutS. Here we… (More)
DOI: 10.1016/j.molcel.2010.06.027

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