Structure of the distal human gonadotropin releasing hormone (hGnrh) gene promoter and functional analysis in Gt1-7 neuronal cells.

@article{Kepa1996StructureOT,
  title={Structure of the distal human gonadotropin releasing hormone (hGnrh) gene promoter and functional analysis in Gt1-7 neuronal cells.},
  author={Jadwiga K. Kepa and A J Spaulding and Britta M Jacobsen and Zhaoqin Fang and Xiaohui Xiong and Sally Radovick and Margaret E. Wierman},
  journal={Nucleic acids research},
  year={1996},
  volume={24 18},
  pages={
          3614-20
        }
}
To assess potential species-specific expression of gonadotropin releasing hormone (GnRH), the distal human (h) GnRH promoter was cloned, characterized and tested in gene transfer studies. The nucleotide sequence of approximately 3.8 kb of 5'-flanking region was determined. Homology to the rat (r) GnRH sequence was observed in the proximal promoter region between -551 h (-424 r) and the transcriptional start site and within multiple distal promoter regions. In contrast, there was little… CONTINUE READING

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