Structure of the cro repressor from bacteriophage lambda and its interaction with DNA.

@article{Anderson1981StructureOT,
  title={Structure of the cro repressor from bacteriophage lambda and its interaction with DNA.},
  author={Wayne F Anderson and Douglas H. Ohlendorf and Yoshinori Takeda and Brian W. Matthews},
  journal={Nature},
  year={1981},
  volume={290 5809},
  pages={754-8}
}
The three-dimensional structure of the 66-amino acid cro repressor protein of bacteriophage lambda suggests how it binds to its operator DNA. We propose that a dimer of cro protein is bound to the B-form of DNA with the 2-fold axis of the dimer coincident with the 2-fold axis of DNA. A pair of 2-fold-related alpha-helices of the repressor, lying within successive major grooves of the DNA, seem to be a major determinant in recognition and binding. In addition, the C-terminal residues of the… CONTINUE READING

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