Structure of the complex of a mitotic kinesin with its calcium binding regulator

  • Maia V. Vinogradovaa, Galina G. Malaninaa, Anireddy S. N. Reddyb, Robert J. Flettericka
  • Published 2009


Much of the transport, tension, and movement in mitosis depends on kinesins, the ATP-powered microtubule-based motors. We report the crystal structure of a kinesin complex, the mitotic kinesin KCBP bound to its principal regulator KIC. Shown to be a Ca2 sensor, KIC works as an allosteric trap. Extensive intermolecular interactions with KIC stabilize kinesin… (More)


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