Structure of the cold- and menthol-sensing ion channel TRPM8

  title={Structure of the cold- and menthol-sensing ion channel TRPM8},
  author={Ying Yin and Mengyu Wu and Lejla Zubcevic and William F Borschel and Gabriel C Lander and Seok-Yong Lee},
Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors that are involved in a variety of physiological processes. Within the TRPM family, member 8 (TRPM8) is the primary cold and menthol sensor in humans. We determined the cryo–electron microscopy structure of the full-length TRPM8 from the collared flycatcher at an overall resolution of ~4.1 ångstroms. Our TRPM8 structure reveals a three-layered architecture. The amino-terminal domain with a fold distinct among… CONTINUE READING
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  • A. Pedretti, C. Marconi, I. Bettinelli, G. Vistoli
  • Biophys. Acta
  • 1788

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