Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of the polypeptides and relation to the Ig superfamily

@article{Burgoon1991StructureOT,
  title={Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of the polypeptides and relation to the Ig superfamily},
  author={Mark P. Burgoon and Martin Grumet and V P Mauro and Gerald M. Edelman and Bruce A. Cunningham},
  journal={The Journal of Cell Biology},
  year={1991},
  volume={112},
  pages={1017 - 1029}
}
The neuron-glia cell adhesion molecule (Ng-CAM) mediates both neuron-neuron and neuron-glia adhesion; it is detected on SDS-PAGE as a predominant 135-kD glycoprotein, with minor components of 80, 190, and 210 kD. We have isolated cDNA clones encoding the entire sequence of chicken Ng-CAM. The predicted extracellular region includes six immunoglobulin-like domains followed by five fibronectin-type III repeats, structural features that are characteristic of several neural CAMs of the N-CAM… CONTINUE READING