Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene.

@article{Hubert1991StructureOT,
  title={Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene.},
  author={C Hubert and A M Houot and Pierre Corvol and F Soubrier},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 23},
  pages={15377-83}
}
  • C Hubert, A M Houot, +1 author F Soubrier
  • Published 1991 in The Journal of biological chemistry
Overlapping genomic clones containing the entire sequence of the human angiotensin I-converting enzyme (ACE) gene were isolated from a lamda phage human DNA library. This gene spans 21 kilobases (kb) and comprises 26 exons, ranging in size from 88 to 481 base pairs. Intron-exon boundaries were sequenced and the relative positions of the exons were mapped. The two different mRNAs transcribed from the ACE gene were assigned to their respective exons. The large endothelial type ACE mRNA (4.3 kb… CONTINUE READING