Structure of the active form of human origin recognition complex and its ATPase motor module

@inproceedings{Tocilj2017StructureOT,
  title={Structure of the active form of human origin recognition complex and its ATPase motor module},
  author={Ante Tocilj and Kin Fan On and Zuanning Yuan and Jingchuan Sun and Elad Elkayam and Huilin Li and Bruce W. Stillman and Leemor Joshua-Tor},
  booktitle={eLife},
  year={2017}
}
Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells. Here, we report the structure of the active form of human ORC determined by X-ray crystallography and cryo-electron microscopy. The complex is composed of an ORC1/4/5 motor module lobe in an organization reminiscent of the DNA polymerase clamp loader complexes. A second lobe contains the ORC2/3 subunits. The complex is organized… CONTINUE READING
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