Structure of the active 27-residue fragment of human calpastatin.

@article{Ishima1991StructureOT,
  title={Structure of the active 27-residue fragment of human calpastatin.},
  author={Rieko Ishima and Atsuo Tamura and Kozo Akasaka and Katsuhiko Hamaguchi and Keisuke Makino and Takashi Murachi and Minoru Hatanaka and Masatoshi Maki},
  journal={FEBS letters},
  year={1991},
  volume={294 1-2},
  pages={64-6}
}
A synthetic 27-residue peptide corresponding to exon 1B of the endogenous inhibitor calpastatin contains a well-conserved region and has an ability to inhibit the cysteine endopeptidase calpain specifically. We examined the solution structure of this peptide in DMSO-d6 by two-dimensional 1H NMR spectroscopy. Although regular secondary structures such as… CONTINUE READING