Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system.

@article{Walldn2012StructureOT,
  title={Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system.},
  author={Karin Walld{\'e}n and Robert Williams and Jun Yan and Pei W Lian and Luchun Wang and Konstantinos Thalassinos and Elena V Orlova and Gabriel Waksman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 28},
  pages={11348-53}
}
Type IV secretion (T4S) systems mediate the transfer of proteins and DNA across the cell envelope of bacteria. These systems play important roles in bacterial pathogenesis and in horizontal transfer of antibiotic resistance. The VirB4 ATPase of the T4S system is essential for both the assembly of the system and substrate transfer. In this article, we present the crystal structure of the C-terminal domain of Thermoanaerobacter pseudethanolicus VirB4. This structure is strikingly similar to that… CONTINUE READING
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