Structure of the VipA/B type VI secretion complex suggests a contraction-state-specific recycling mechanism.

@article{Kube2014StructureOT,
  title={Structure of the VipA/B type VI secretion complex suggests a contraction-state-specific recycling mechanism.},
  author={Sebastian Kube and Nicole Kapitein and Tomasz Zimniak and Franz Herzog and Axel Mogk and Petra Wendler},
  journal={Cell reports},
  year={2014},
  volume={8 1},
  pages={20-30}
}
The bacterial type VI secretion system is a multicomponent molecular machine directed against eukaryotic host cells and competing bacteria. An intracellular contractile tubular structure that bears functional homology with bacteriophage tails is pivotal for ejection of pathogenic effectors. Here, we present the 6 Å cryoelectron microscopy structure of the contracted Vibrio cholerae tubule consisting of the proteins VipA and VipB. We localized VipA and VipB in the protomer and identified… CONTINUE READING
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