Structure of the Vdelta domain of a human gammadelta T-cell antigen receptor.

@article{Li1998StructureOT,
  title={Structure of the Vdelta domain of a human gammadelta T-cell antigen receptor.},
  author={Hongyun Li and Marina I. Lebedeva and Andrea S. Llera and Barry A. Fields and Michael B Brenner and Roy A. Mariuzza},
  journal={Nature},
  year={1998},
  volume={391 6666},
  pages={502-6}
}
Antigen recognition by T lymphocytes is mediated by cell-surface glycoproteins known as T-cell antigen receptors (TCRs). These are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. In contrast to alphabeta TCRs, which recognize antigen only as peptide fragments bound to molecules of the major histocompatibility complex (MHC), gammadelta TCRs appear to recognize proteins directly, without antigen processing, and to recognize MHC… CONTINUE READING
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