Structure of the T15 VH gene subfamily: identification of immunoglobulin gene promotor homologies.

@article{Siu1987StructureOT,
  title={Structure of the T15 VH gene subfamily: identification of immunoglobulin gene promotor homologies.},
  author={Gerald Siu and E A Springer and Henry Huang and Leroy E. Hood and Stephen T. Crews},
  journal={Journal of immunology},
  year={1987},
  volume={138 12},
  pages={4466-71}
}
We have sequenced and analyzed the flanking and coding regions of four closely related mouse VH gene segments referred to as the T15 gene subfamily. We have found that although the sequence homologies between the four members of this family are greatest in the coding region, significant homologies extend into the leader sequences and the flanking regions as well. Sequence comparisons of the promoter regions of other VH gene segments indicate that the octamer promoter sequence is part of a… CONTINUE READING