Structure of the Synthetic Polypeptide Poly-γ-methyl-L-glutamate

  title={Structure of the Synthetic Polypeptide Poly-$\gamma$-methyl-L-glutamate},
  author={Harry L. Yakel and Linus Carl Pauling and Robert B. Corey},
WE have made a check on the assignment of the α-helix with eighteen residues in five turns to poly-γ-methyl-L-glutamate1 by preparing and interpreting X-ray photographs of a sample of the material. The results obtained not only support the assignment, but also indicate that the β-carbon atoms are in position 2 rather than in position 1 2. This is the same assignment of the β-carbon atoms as that made by Riley and Arndt3 for serum albumin, on the basis of their determination of the radial… 
12 Citations
Is α-Keratin a Coiled Coil?
ALL recent work1–6 has confirmed that the structure of the synthetic polypeptide poly-γ-methyl-L-glutamate is based on the α-helix of Pauling and Corey7. This structure gives a strong 1.5-A.
Synthesis and chemical properties of poly-alpha-amino acids.
The chemistry of keratins.
Polymerization of NCAs: Physical Aspects
The great interest numerous research groups had, and still have, in the molecular weights and molecular weight distributions (MWDs) of polypeptides prepared by polymerization of NCAs has two sources.
Optical diffractometer for facilitation of x-ray diffraction studies of macromolecular structures.
An instrument employing optical analogies to the diffraction of x-rays by macromolecular substances is described, using the diffractometer to synthesize images of structures from masks simulating observed x-ray diffraction.
Gitterstruktur der hochpolymeren Stoffe
In der Rontgenstrukturanalyse der makromolekularen Stoffe haben wir die beiden Falle zu unterscheiden, das makroskopische Einkristalle erhalten werden konnen, wie vor allem bei vielen loslichen
Fibrils and filaments of muscle proteins as examples of molecular complexes.
  • R. Bear
  • Biology
    Journal of cellular physiology. Supplement
  • 1957


The structure of synthetic polypeptides.
  • L. Pauling, R. Corey
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1951
Evidence that one of the helical structures is assumed also by synthetic polypeptides is discussed, which is an important structural feature of hemoglobin and other globular proteins.
Evidence for the Pauling–Corey α-Helix in Synthetic Polypeptides
It is shown here that the correspondence extends over the whole of the diffraction pattern of the synthetic polypeptide poly-γ-methyl-L-glutamate, so readily explained on this basis as to leave little doubt that the Pauling–Corey α-helix2, or some close approximation to it, exists in this polypeptic.
Atomic coordinates and structure factors for two helical configurations of polypeptide chains.
  • L. Pauling, R. Corey
  • Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1951
The discovery of two helical configurations of the polypeptide chain that satisfy the conditions for diffraction of x-rays in the equatorial direction are reported.