Structure of the SRP19–RNA complex and implications for signal recognition particle assembly

@article{Hainzl2002StructureOT,
  title={Structure of the SRP19–RNA complex and implications for signal recognition particle assembly},
  author={T. Hainzl and S. Huang and A. E. Sauer-Eriksson},
  journal={Nature},
  year={2002},
  volume={417},
  pages={767-771}
}
  • T. Hainzl, S. Huang, A. E. Sauer-Eriksson
  • Published 2002
  • Biology, Medicine
  • Nature
  • The signal recognition particle (SRP) is a phylogenetically conserved ribonucleoprotein. It associates with ribosomes to mediate co-translational targeting of membrane and secretory proteins to biological membranes. In mammalian cells, the SRP consists of a 7S RNA and six protein components. The S domain of SRP comprises the 7S.S part of RNA bound to SRP19, SRP54 and the SRP68/72 heterodimer; SRP54 has the main role in recognizing signal sequences of nascent polypeptide chains and docking SRP… CONTINUE READING

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