Structure of the RsbX phosphatase involved in the general stress response of Bacillus subtilis.

@article{Teh2015StructureOT,
  title={Structure of the RsbX phosphatase involved in the general stress response of Bacillus subtilis.},
  author={Aik Hong Teh and Masatomo Makino and Takeshi Hoshino and Seiki Baba and Nobutaka Shimizu and Masaki Yamamoto and Takashi Kumasaka},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2015},
  volume={71 Pt 6},
  pages={
          1392-9
        }
}
In the general stress response of Bacillus subtilis, which is governed by the sigma factor σ(B), stress signalling is relayed by a cascade of Rsb proteins that regulate σ(B) activity. RsbX, a PPM II phosphatase, halts the response by dephosphorylating the stressosome composed of RsbR and RsbS. The crystal structure of RsbX reveals a reorganization of the catalytic centre, with the second Mn(2+) ion uniquely coordinated by Gly47 O from the β4-α1 loop instead of a water molecule as in PPM I… CONTINUE READING
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