Structure of the RCK Domain from the E. coli K+ Channel and Demonstration of Its Presence in the Human BK Channel

  title={Structure of the RCK Domain from the E. coli K+ Channel and Demonstration of Its Presence in the Human BK Channel},
  author={Y. Jiang and A. Pico and M. Cad{\`e}ne and B. Chait and R. MacKinnon},
  • Y. Jiang, A. Pico, +2 authors R. MacKinnon
  • Published 2001
  • Biology, Medicine
  • Neuron
  • The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K+ transporters and K+ channels. The RCK domain has a Rossmann-fold topology with unique positions, not commonly conserved among Rossmann-fold proteins, composing a well-conserved… CONTINUE READING
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