Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors

@inproceedings{Falk2016StructureOT,
  title={Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors},
  author={Sebastian Falk and Ksenia Finogenova and Mireille Melko and Christian Benda and S\oren Lykke-Andersen and Torben Heick Jensen and Elena Conti},
  booktitle={Nature communications},
  year={2016}
}
The eukaryotic RNA exosome participates extensively in RNA processing and degradation. In human cells, three accessory factors (RBM7, ZCCHC8 and hMTR4) interact to form the nuclear exosome targeting (NEXT) complex, which directs a subset of non-coding RNAs for exosomal degradation. Here we elucidate how RBM7 is incorporated in the NEXT complex. We identify a proline-rich segment of ZCCHC8 as the interaction site for the RNA-recognition motif (RRM) of RBM7 and present the crystal structure of… CONTINUE READING
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