Structure of the PilM-PilN inner membrane type IV pilus biogenesis complex from Thermus thermophilus.

@article{Karuppiah2011StructureOT,
  title={Structure of the PilM-PilN inner membrane type IV pilus biogenesis complex from Thermus thermophilus.},
  author={Vijaykumar Karuppiah and Jeremy P Derrick},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 27},
  pages={
          24434-42
        }
}
Type IV pili are surface-exposed filaments, which extend from a variety of bacterial pathogens and play a major role in pathogenesis, motility, and DNA uptake. Here, we present the crystal structure of a complex between a cytoplasmic component of the type IV pilus biogenesis system from Thermus thermophilus, PilM, in complex with a peptide derived from the cytoplasmic portion of the inner membrane protein PilN. PilM also binds ATP, and its structure is most similar to the actin-like protein… CONTINUE READING

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