Structure of the PIN/LC8 dimer with a bound peptide

  title={Structure of the PIN/LC8 dimer with a bound peptide},
  author={Jun Liang and Samie R. Jaffrey and Wei Guo and Solomon H Snyder and Jon Clardy},
  journal={Nature Structural Biology},
The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8 monomers related by a two-fold axis form a rectangular dimer. Two pairs of α-helices cover opposite faces, and each pair of helices packs against a β-sheet with five antiparallel β-strands. Each five-stranded β-sheet contains four strands from one monomer and a fifth strand… CONTINUE READING
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