Structure of the OSR1 kinase, a hypertension drug target.

@article{Villa2008StructureOT,
  title={Structure of the OSR1 kinase, a hypertension drug target.},
  author={Fabrizio Villa and M{\'a}ria De{\'a}k and Dario R Alessi and Daan M F van Aalten},
  journal={Proteins},
  year={2008},
  volume={73 4},
  pages={
          1082-7
        }
}
The oxidative stress-responsive kinase-1 (OSR1) and STE20/SPS1-related proline/alanine-rich kinase (SPAK) interact, phosphorylate, and stimulate the activity of the cation-chloride cotransporters (NKCC1, NKCC2, and the Na1:Cl2 cotransporter (NCC)).1–4 These cotransporters play key roles in regulating salt intake and secretion from cells (reviewed in Refs. 5,6). Some of the most commonly prescribed blood pressure-lowering thiazide drugs exert their physiological effects by inhibiting NCC. The… CONTINUE READING
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Crystal structures of F. Villa et al. 1086 PROTEINS the p21-activated kinases PAK4. PAK5 and PAK6 reveal catalytic domain plasticity of active group II PAKs

  • JLW Eswaran, JE Debreczeni, +5 authors S. Knapp
  • Structure
  • 2007
Highly Influential
7 Excerpts

Ks and hypertension: important leads from the study of monogenetic disorders of blood pressure regulation

  • PW Flatman, WN Cotransporters
  • Clin Sci ( Lond )
  • 2007
Highly Influential
7 Excerpts

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