Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin.

@article{Hemmerich1995StructureOT,
  title={Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin.},
  author={Stefan Hemmerich and Hakon Leffler and S D Rosen},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 20},
  pages={
          12035-47
        }
}
L-selectin, the leukocyte selectin, mediates the carbohydrate-dependent attachment of circulating leukocytes to endothelium, preceding emigration into tissues. It functions in inflammatory leukocyte trafficking and in lymphocyte homing to lymph nodes. From previous work, the binding of L-selectin to endothelial-associated glycoprotein ligands, GlyCAM-1 and CD34, requires oligosaccharide sialylation, sulfation, and probably fucosylation. We have recently identified a major capping group in… CONTINUE READING
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