Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF.

@article{Burtnick2004StructureOT,
  title={Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF.},
  author={Leslie D. Burtnick and Dunja Urosev and Edward Irobi and Kartik Narayan and Robert C Robinson},
  journal={The EMBO journal},
  year={2004},
  volume={23 14},
  pages={2713-22}
}
The actin filament-severing functionality of gelsolin resides in its N-terminal three domains (G1-G3). We have determined the structure of this fragment in complex with an actin monomer. The structure reveals the dramatic domain rearrangements that activate G1-G3, which include the replacement of interdomain interactions observed in the inactive, calcium-free protein by new contacts to actin, and by a novel G2-G3 interface. Together, these conformational changes are critical for actin filament… CONTINUE READING

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