Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II

@article{Robinson2012StructureOT,
  title={Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II},
  author={Philip J. J. Robinson and D. Bushnell and M. Trnka and A. Burlingame and R. Kornberg},
  journal={Proceedings of the National Academy of Sciences},
  year={2012},
  volume={109},
  pages={17931 - 17935}
}
The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for Mediator–CTD interaction for transcription. 
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