Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation.

@article{Niu2013StructureOT,
  title={Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation.},
  author={Fengfeng Niu and Neil A. Shaw and Yao E. Wang and Lianying Jiao and Wei Ding and Xiaomin Li and Ping Zhu and Halmurat Upur and Songying Ouyang and Genhong Cheng},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 22},
  pages={9054-9}
}
Negative-stranded RNA viruses cover their genome with nucleoprotein (N) to protect it from the human innate immune system. Abrogation of the function of N offers a unique opportunity to combat the spread of the viruses. Here, we describe a unique fold of N from Leanyer virus (LEAV, Orthobunyavirus genus, Bunyaviridae family) in complex with single-stranded RNA refined to 2.78 Å resolution as well as a 2.68 Å resolution structure of LEAV N-ssDNA complex. LEAV N is made up of an N- and a C… CONTINUE READING
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