Structure of the Human Transferrin Receptor-Transferrin Complex

@article{Cheng2004StructureOT,
  title={Structure of the Human Transferrin Receptor-Transferrin Complex},
  author={Yifan Cheng and Olga Dipl.-Ing. Zak and Philip Aisen and Stephen C. Harrison and Thomas Walz},
  journal={Cell},
  year={2004},
  volume={116},
  pages={565-576}
}
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of the receptor-transferrin complex. Using cryo-electron microscopy, we have produced a density map of the TfR-Tf complex at subnanometer… Expand
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The results confirm the previous finding that Fe-Tf and HFE compete for the receptor by binding to an overlapping site on the TfR helical domain and propose a structure-based model for the mechanism of T fR-assisted iron release from Fe-tf. Expand
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