Structure of the Human Telomeric Stn1-Ten1 Capping Complex

@inproceedings{Bryan2013StructureOT,
  title={Structure of the Human Telomeric Stn1-Ten1 Capping Complex},
  author={Christopher Bryan and Cory T Rice and Michael J Harkisheimer and David C. Schultz and Emmanuel Skordalakes},
  booktitle={PloS one},
  year={2013}
}
The identification of the human homologue of the yeast CST in 2009 posed a new challenge in our understanding of the mechanism of telomere capping in higher eukaryotes. The high-resolution structure of the human Stn1-Ten1 (hStn1-Ten1) complex presented here reveals that hStn1 consists of an OB domain and tandem C-terminal wHTH motifs, while hTen1 consists… CONTINUE READING