Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7*

  title={Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7*},
  author={C. D. Lima and D. Reverter},
  journal={Journal of Biological Chemistry},
  pages={32045 - 32055}
  • C. D. Lima, D. Reverter
  • Published 2008
  • Biology, Medicine
  • Journal of Biological Chemistry
  • Small ubiquitin-like modifier (SUMO) proteases regulate the abundance and lifetime of SUMO-conjugated substrates by antagonizing reactions catalyzed by SUMO-conjugating enzymes. Six SUMO proteases constitute the human SENP/ULP protease family (SENP1-3 and SENP5-7). SENP6 and SENP7 include the most divergent class of SUMO proteases, which also includes the yeast enzyme ULP2. We present the crystal structure of the SENP7 catalytic domain at a resolution of 2.4Å. Comparison with structures of… CONTINUE READING
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