Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9


Specific modifications to histones are essential epigenetic markers—heritable changes in gene expression that do not affect the DNA sequence. Methylation of lysine 9 in histone H3 is recognized by heterochromatin protein 1 (HP1), which directs the binding of other proteins to control chromatin structure and gene expression. Here we show that HP1 uses an… (More)
DOI: 10.1038/nature722

4 Figures and Tables


  • Presentations referencing similar topics