Structure of the Glycosyltransferase EryC 11 I in Complex with its Activating P 450 Homologue EryCII

In the biosynthesis of the clinically important antibiotic erythromycin D, the glycosyltransferase (GT) EryCIII, in concert with its partner EryCII, attaches a nucleotide-activated sugar to the macrolide scaffold with high specificity. To understand the role of EryCII, we have determined the crystal structure of the EryCm·EryCII complex at 3.1 A resolution… CONTINUE READING