Structure of the FMNL3 FH2/actin complex provides insight into formin-mediated actin nucleation and elongation

@inproceedings{Thompson2013StructureOT,
  title={Structure of the FMNL3 FH2/actin complex provides insight into formin-mediated actin nucleation and elongation},
  author={Morgan E. Thompson and Ernest G Heimsath and Timothy J. Gauvin and Henry N Higgs and F Jon Kull},
  booktitle={Nature Structural &Molecular Biology},
  year={2013}
}
Formins are actin-assembly factors that act in a variety of actin-based processes. The conserved formin homology 2 (FH2) domain promotes filament nucleation and influences elongation through interaction with the barbed end. FMNL3 is a formin that induces assembly of filopodia but whose FH2 domain is a poor nucleator. The 3.4-Å structure of a mouse FMNL3 FH2 dimer in complex with tetramethylrhodamine-actin uncovers details of formin-regulated actin elongation. We observe distinct FH2 actin… CONTINUE READING