Structure of the Extracellular Region of HER3 Reveals an Interdomain Tether

@article{Cho2002StructureOT,
  title={Structure of the Extracellular Region of HER3 Reveals an Interdomain Tether},
  author={Hyun-soo Cho and Daniel J. Leahy},
  journal={Science},
  year={2002},
  volume={297},
  pages={1330 - 1333}
}
We have determined the 2.6 angstrom crystal structure of the entire extracellular region of human HER3 (ErbB3), a member of the epidermal growth factor receptor (EGFR) family. The structure consists of four domains with structural homology to domains found in the type I insulin-like growth factor receptor. The HER3 structure reveals a contact between domains II and IV that constrains the relative orientations of ligand-binding domains and provides a structural basis for understanding both… 

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