Structure of the Escherichia coli ribosomal termination complex with release factor 2

@article{Klaholz2003StructureOT,
  title={Structure of the Escherichia coli ribosomal termination complex with release factor 2},
  author={Bruno P. Klaholz and Tillmann Pape and Andrey V. Zavialov and Alexander G. Myasnikov and Elena V Orlova and Bente Vestergaard and M{\aa}ns Ehrenberg and Marin van Heel},
  journal={Nature},
  year={2003},
  volume={421},
  pages={90-94}
}
Termination of protein synthesis occurs when the messenger RNA presents a stop codon in the ribosomal aminoacyl (A) site. Class I release factor proteins (RF1 or RF2) are believed to recognize stop codons via tripeptide motifs, leading to release of the completed polypeptide chain from its covalent attachment to transfer RNA in the ribosomal peptidyl (P) site. Class I RFs possess a conserved GGQ amino-acid motif that is thought to be involved directly in protein–transfer-RNA bond hydrolysis… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

Evolution of the Protein Synthesis Machinery and Its Regulation

Greco Hern, ndez, Rosemary Jagus
Springer International Publishing • 2016

A Ribosome Without RNA

Front. Ecol. Evol. • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Crystal structure of the ribosome at 5 . 5 A resolution

M. M. Yusupov
Science • 2001

Similar Papers

Loading similar papers…