Structure of the Elk-1–DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA

@article{Mo2000StructureOT,
  title={Structure of the Elk-1–DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA},
  author={Yi Mo and Benjamin Vaessen and Karen Johnston and Ronen Marmorstein},
  journal={Nature Structural Biology},
  year={2000},
  volume={7},
  pages={292-297}
}
SAP-1 and Elk-1 are members of a large group of eukaryotic transcription factors that contain a conserved ETS DNA binding domain and that cooperate with the serum response factor (SRF) to activate transcription of the c-fos protooncogene. Despite the high degree of sequence similarity, which includes an identical amino acid sequence for the DNA recognition helix within the ETS domain of these proteins, they exhibit different DNA binding properties. Here we report the 2.1 Å crystal structure of… CONTINUE READING
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