Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

@inproceedings{MartinezZapien2016StructureOT,
  title={Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53},
  author={Denise Martinez-Zapien and Francesc Xavier Ruiz and Juline Poirson and Andr{\'e} Mitschler and Juan Ramon Ramirez-Ramos and Anne Forster and Alexandra Cousido-Siah and Murielle Masson and Scott B Vande Pol and Alberto D Podjarny and Gilles Trav{\'e} and Katia Zanier},
  booktitle={Nature},
  year={2016}
}
The p53 pro-apoptotic tumour suppressor is mutated or functionally altered in most cancers. In epithelial tumours induced by ‘high-risk’ mucosal human papilloma viruses, including human cervical carcinoma and a growing number of head-and-neck cancers, p53 is degraded by the viral oncoprotein E6 (ref. 2). In this process, E6 binds to a short leucine (L)-rich… CONTINUE READING