Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

@article{Chen2008StructureOT,
  title={Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G},
  author={Kuan-Ming Chen and E. Harjes and Phillip J. Gross and Amr F Fahmy and Yongjian Lu and K. Shindo and R. Harris and H. Matsuo},
  journal={Nature},
  year={2008},
  volume={452},
  pages={116-119}
}
The human APOBEC3G (apolipoprotein B messenger-RNA-editing enzyme, catalytic polypeptide-like 3G) protein is a single-strand DNA deaminase that inhibits the replication of human immunodeficiency virus-1 (HIV-1), other retroviruses and retrotransposons. APOBEC3G anti-viral activity is circumvented by most retroelements, such as through degradation by HIV-1 Vif. APOBEC3G is a member of a family of polynucleotide cytosine deaminases, several of which also target distinct physiological substrates… Expand

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