Structure of the Core Ectodomain of the Hepatitis C Virus Envelope Glycoprotein 2

  title={Structure of the Core Ectodomain of the Hepatitis C Virus Envelope Glycoprotein 2},
  author={Abdul Ghafoor Khan and Jillian Whidby and Matthew Thomas Miller and Hannah Scarborough and Alexandra V. Zatorski and Alicja Cygan and Aryn A. Price and Samantha A. Yost and Caitlin D. Bohannon and Joshy Jacob and Arash Grakoui and Joseph Marcotrigiano},
Hepatitis C virus (HCV) is a significant public health concern with approximately 160 million people infected worldwide. HCV infection often results in chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. No vaccine is available and current therapies are effective against some, but not all, genotypes. HCV is an enveloped virus with two surface glycoproteins (E1 and E2). E2 binds to the host cell through interactions with scavenger receptor class B type I (SR-BI) and CD81, and serves… CONTINUE READING
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