Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033.

@article{Wang2001StructureOT,
  title={Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033.},
  author={Xu Wang and Monica X. Li and Leo Spyracopoulos and Norbert Beier and Murali Chandra and R. John Solaro and Brian D. Sykes},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 27},
  pages={25456-66}
}
Ca(2+) binding to cardiac troponin C (cTnC) triggers contraction in heart muscle. In heart failure, myofilaments response to Ca(2+) are often altered and compounds that sensitize the myofilaments to Ca(2+) possess therapeutic value in this syndrome. One of the most potent and selective Ca(2+) sensitizers is the thiadiazinone derivative EMD 57033, which increases myocardial contractile function both in vivo and in vitro and interacts with cTnC in vitro. We have determined the NMR structure of… CONTINUE READING

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