Structure of the Bcr-Abl oncoprotein oligomerization domain


The Bcr-Abl oncoprotein is responsible for a wide range of human leukemias, including most cases of Philadelphia chromosome-positive chronic myelogenous leukemia. Oligomerization of Bcr-Abl is essential for oncogenicity. We determined the crystal structure of the N-terminal oligomerization domain of Bcr-Abl (residues 1–72 or Bcr1–72) and found a novel mode… (More)
DOI: 10.1038/nsb747


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@article{Zhao2002StructureOT, title={Structure of the Bcr-Abl oncoprotein oligomerization domain}, author={Xun Zhao and Saghi Ghaffari and Harvey F. Lodish and Vladimir N. Malashkevich and Peter S. Kim}, journal={Nature Structural Biology}, year={2002}, volume={9}, pages={117-120} }