Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme

@article{Rosenberg2005StructureOT,
  title={Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme},
  author={Oren S. Rosenberg and Sebastian Deindl and Rou-Jia Sung and Angus C. Nairn and John Kuriyan},
  journal={Cell},
  year={2005},
  volume={123},
  pages={849-860}
}
Ca2+/calmodulin-dependent protein kinase-II (CaMKII) is unique among protein kinases for its dodecameric assembly and its complex response to Ca2+. The crystal structure of the autoinhibited kinase domain of CaMKII, determined at 1.8 A resolution, reveals an unexpected dimeric organization in which the calmodulin-responsive regulatory segments form a coiled-coil strut that blocks peptide and ATP binding to the otherwise intrinsically active kinase domains. A threonine residue in the regulatory… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS