Structure of the Amantadine Binding Site of Influenza M2 Proton Channels In Lipid Bilayers

@inproceedings{Cady2010StructureOT,
  title={Structure of the Amantadine Binding Site of Influenza M2 Proton Channels In Lipid Bilayers},
  author={Sarah D. Cady and Klaus Schmidt-Rohr and Jun Wang and Cinque S. Soto and William F. DeGrado and Mei Hong},
  booktitle={Nature},
  year={2010}
}
The M2 protein of influenza A virus is a membrane-spanning tetrameric proton channel targeted by the antiviral drugs amantadine and rimantadine. Resistance to these drugs has compromised their effectiveness against many influenza strains, including pandemic H1N1. A recent crystal structure of M2(22–46) showed electron densities attributed to a single amantadine in the amino-terminal half of the pore, indicating a physical occlusion mechanism for inhibition. However, a solution NMR structure of… CONTINUE READING
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