Structure of the A2m(1) allotype of human IgA--a recombinant molecule.

  title={Structure of the A2m(1) allotype of human IgA--a recombinant molecule.},
  author={Y Tsuzukida and Cheng Chih Wang and Frank W. Putnam},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={76 3},
The complete amino-acid sequence of the constant (C) region of the alpha2 heavy chain of a human IgA2 protein of the A2m(1) allotype has been determined. Excluding the hinge region and the carbohydrate content, this alpha2 allotype differs from the alpha1 chain in only 14 amino-acid positions; all of these are identical to the A2m(2) allotype of the alpha2 chain and confer subclass (or isotypic) character on the alpha2 chains. However, the A2m(2) allotype differs in six positions where A2m(1… CONTINUE READING

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