Structure of the A Site of Escherichia coli 16S Ribosomal RNA Complexed with an Aminoglycoside Antibiotic

@article{Fourmy1996StructureOT,
  title={Structure of the A Site of Escherichia coli 16S Ribosomal RNA Complexed with an Aminoglycoside Antibiotic},
  author={D. Fourmy and M. Recht and S. Blanchard and J. Puglisi},
  journal={Science},
  year={1996},
  volume={274},
  pages={1367 - 1371}
}
Aminoglycoside antibiotics that bind to 30S ribosomal A-site RNA cause misreading of the genetic code and inhibit translocation. The aminoglycoside antibiotic paromomycin binds specifically to an RNA oligonucleotide that contains the 30S subunit A site, and the solution structure of the RNA-paromomycin complex was determined by nuclear magnetic resonance spectroscopy. The antibiotic binds in the major groove of the model A-site RNA within a pocket created by an A-A base pair and a single bulged… Expand
Structural origins of gentamicin antibiotic action
Structural origins of aminoglycoside specificity for prokaryotic ribosomes.
Binding of neomycin-class aminoglycoside antibiotics to the A-site of 16 S rRNA.
Paromomycin binding induces a local conformational change in the A-site of 16 S rRNA.
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