Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release.

@article{Jin2010StructureOT,
  title={Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release.},
  author={Hong Jin and Ann C. Kelley and D. Loakes and Venkatraman Ramakrishnan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 19},
  pages={8593-8}
}
We report the crystal structure of release factor 2 bound to ribosome with an aminoacyl tRNA substrate analog at the ribosomal P site, at 3.1 A resolution. The structure shows that upon stop-codon recognition, the universally conserved GGQ motif packs tightly into the peptidyl transferase center. Nucleotide A2602 of 23S rRNA, implicated in peptide release, packs with the GGQ motif in release factor 2. The ribose of A76 of the peptidyl-tRNA adopts the C2'-endo conformation, and the 2' hydroxyl… CONTINUE READING
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