Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold.

@article{Conte2000StructureOT,
  title={Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold.},
  author={Maria R. Conte and Tim Gruene and Jamie Ghuman and Geoff P. Kelly and Aristea Ladas and S. G. Matthews and S. K. Curry},
  journal={The EMBO journal},
  year={2000},
  volume={19 12},
  pages={3132-41}
}
Polypyrimidine tract binding protein (PTB), an RNA binding protein containing four RNA recognition motifs (RRMs), is involved in both pre-mRNA splicing and translation initiation directed by picornaviral internal ribosome entry sites. Sequence comparisons previously indicated that PTB is a non-canonical RRM protein. The solution structure of a PTB fragment containing RRMs 3 and 4 shows that the protein consists of two domains connected by a long, flexible linker. The two domains tumble… CONTINUE READING
57 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

Similar Papers

Loading similar papers…